As Jake and Futura attempt to rescue Tracy. Eddie gets lost and is worshipped by the Egyptians as the ghost of the Great Pharoah. The Ghostbusters must race to get their act together in an effort to locate the next piece of the Stone Tablet.

The Ghostbusters race back in time to rescue Futura from Prime Evil at a Salem witch trial. They must not only stop the villain's latest plan, but they must convince the townsfolk that they are not evil spirits.

When Jake and Jessica go on a date Eddie and Tracy go to the rescue of a little girl which turns out to be a trap laid by Prime Evil and find themselves in an old ghost town where they meet a good ghost named Sheriff Stumbleweed and learn that Prime Evil has brought together the most fearsome ghosts from across the universe.

Big Evil returns to Hauntquarters and curses Prime Evil with the Arcane Curse, a spell that can only be broken by performing a geniune heartfelt good deed. A battle between Prime Evil and Big Evil takes place at Ghost Command with no winner in sight for the Ghostbusters.

The Ghostbusters travel to Norway to guard peace prize winner Dr. Alex Miller and Jessica from Prime Evil's latest ghostly plan. The gang not only has to protect Dr. Miller from Apparitia and Scared Stiff, but also stop the runaway train they find themselves on.

When Prime Evil's cousin, Count Grumpette creates a double of Tracy using some of the ape's hairs he sends the clone to create havoc. The Ghostbusters are shocked when Tracy is imprisoned and vow to prove their friend's innocence.

Madam Why receives a gift that turns out to be from Prime Evil and spirits her away as his captive in Hauntquaters. Using her as bait he captures the Ghostbusters, so its up Futura and Jessica to save the day.

In his latest plan to rule the world Prime Evil decides to amplify Belfry's sonic blast. However things do not go according to plan when his sister Prime Ordeal and her bratty child Snookums arrive. As the Ghostbusters fight to save Belfry, Prime Evil is occupied with many other problems!