Basking in the adulation from his latest movie premiere, Hollywood 'it' actor Vince Chase joins childhood pals Eric, Drama and Turtle to debate the pros and cons of attending their tenth high-school reunion back east. Meanwhile, Eric – Vince's de facto manager – incurs the wrath of Vince's agent Ari by advising Vince to pass on a script he hasn't even read. On the domestic-security front, Turtle agrees to test the mettle of the entourage's new guard dog, a Rottweiler named Ahnold.

Ignoring the cautionary portents of a negative review, Vince ramps up his already-excessive spending by leasing a new Rolls-Royce. Ari urges Vince to get a "real" manager, causing a wounded Eric to do some soul-searching. Meanwhile, Drama skips a "Vagina Monologues" rehearsal (go figure) to join Vince and the entourage at a wild party hosted by a sexy actress.

After meeting a talk-show host at a boxing after-party in L.A., Vince agrees to appear on his show – despite a long-standing rift between the host and Drama. Eric and Kristen share a long goodbye; Ari puts the full-court press on a famous comic; and Luke Wilson tells Turtle how to score a free home-theater system for Vince.

Vince decides to celebrate the opening night of his latest movie, 'Head On,' with a group date – to Eric's chagrin. Drama's pumped-up gal pal Tanya struts her stuff at a bowling alley; Turtle taps into Vince's fan mail for some action; and Vince turns on the charm with unsullied pop vixen Justine Chaplin.

Vince's fling with a 'cruelty-free' vegan named Fiona – and her friendship with a laid-back L.A. 'sherpa' – brings unexpected karma to the entourage. Eric pushes a promising new script set in Queens; Drama fears the disruptive power of his friends' new relationships; and Turtle barters boots for booty.

Ari's former assistant Josh, now a competing agent, woos Vince and the boys at a wild Malibu beach party. Drama ponders an alternate career in the food-service industry; Eric puts Emily in a compromising position; and Turtle irritates an actor at an art opening.

Eric is concerned over the choice of director, an indie loose cannon named Billy Walsh, for Vince's new film. Meanwhile, Drama lobbies for a supporting role, while Ari finds he can't mix business with pleasure.

Sick of being known as 'Vince's guy,' Eric wants a title commensurate with his responsibilities. With his latest shoot taking him to New York for three months, Vince prepares to say goodbye to L.A. – as well as his many 'special' girlfriends. Meanwhile, Drama debates taking either a high-paying TV role or a low-paying film gig, and Turtle stakes out a claim as Vince's 'farewell party' promoter.

The guys go to extremes to keep Vince away from temptation after he gets out of rehab, but they're also worried about triggering a relapse when he's excited about a lame idea for a movie. Meanwhile, Ari pleads with his wife to end their separation, and Eric and Scott court new clients for their fledgling management company.

After writing a 20-page outline for his movie idea, Vince asks Billy to give it a once over. Ari finds out that Mrs. Gold may be lowering her standards after a tip from Lloyd. Drama's "Johnny's Bananas" costar Andrew Dice Clay needs representation, and leaves Drama reeling after getting an idea. Turtle consistently fails to get Alex on the phone. A miscommunication between Eric and Sloan turns into an encounter that Eric will not forget, yet will want to.

A benevolent Vince defies his friends' advice and gives an old nemesis, producer Carl Ertz, a second chance when he claims to be interested in the miner movie. Meanwhile, Andrew Dice Clay takes a stand on his "Johnny's Bananas" contract despite Drama's disapproval. Lloyd convinces Ari to go on a date, and Turtle has a meeting with his boss about his future with Avion.

Shauna goes into damage-control mode when Vince must pass a drug test after being caught in a compromising position. Ari escorts an old flame to Bobby Flay's restaurant to get back at his wife following a rancorous session of couples therapy.

Dissatisfied with his new "Johnny's Bananas" costar, Drama hatches a plan to bring Andrew Dice Clay back to the show. Meanwhile, Vince tries to do his own damage control with a Vanity Fair interview, Eric bonds with Sloan's ex-stepmother over their romantic woes, and Ari's recent tryst makes for an awkward business meeting with Dana Gordon.

Ari gets unsettling news from his lawyer about his divorce. Eric is floored by a gift from Melinda Clarke, but unnerved by a revelation from Johnny Galecki. Vince deals with the fallout from his interview and Turtle meets his new business partners.

Turtle turns to his investors for more money when his new business partners eye an expensive property. Meanwhile, Eric and Melinda crash Sloan's date, the miner movie gets personal for Ari, and Vince woos Sophia.

Vince takes a surprising step after a first date with Sophia. A therapy session yields mixed results for Ari and Mrs. Ari, and Vince, Drama and Turtle urge Sloan to work things out with Eric.