When a 14-year-old violinist disappears on the night of a concert, the team follows her and her valuable violin's trail and Samantha bravely tries to recover from the gunshot wound.

The team search for a Doctor that has disappeared after a jog in the city with her ex-husband

When the team searches whether foul play was involved in the adoption of a 16-year-old girl who went missing back in 1991 shows up at the FBI offices with an article she found online, which makes her believe she was kidnapped as a young child. Meanwhile, Jack tells the team he's moving to Chicago with his family.

When Stephanie Healy doesn't show up for choir practice, the team heads in to investigate and soon learns Stephanie had recently had a fight with her boyfriend. While speaking with Eddie, the team is shocked to learn that Stephanie used to be Stephen Patrick Healy. Convinced that the truth to what is happening in Stephanie's present lies in her past, the team investigates who Stephen was. Vivian has trouble hiding her worsening problems from the team, and is upset that Martin has been talking to Sam about his suspicions.

Danny is skeptical when the pregnant girlfriend of his missing estranged brother, Rafael ""Rafi"" Alvarez, and mother of their 9-year-old son, tells him that Rafi has transformed himself into a responsible family man, who recently obtained a loan to open his own body shop. But Danny's investigation uncovers that Rafi has been seen with a convicted car thief, and the large sum of cash he'd been flaunting for his purchase of a body shop didn't come from the bank. Though Jack makes the point that Rafi may have legitimate explanations for the suspicious circumstances, Danny braces himself for the very real possibility that his brother may have put himself in harm's way.

After therapist Gina Hill disappears, the team investigates and initially suspects that one of her patients may be involved. After discussions with Gina's fiancé and her own therapist, the team follows the trail of clues to a bartender named Vince with an unusual ability to get good women to do whatever he wants them to. Martin continues to struggle with his recovery.

The team investigates when Aaron Gibbs ends up missing one night and soon learn that he had been lying to his wife about quitting his job, and had been working nights in a fight club. During the course of the investigation, Jack and the others learn that Aaron's disappearance was connected to events that took place during Hurricane Katrina, when Aaron was fighting to save his sons, and follow the trail of evidence, believing that the events of that night in New Orleans hold the key to finding the truth about the missing man.