With an entire town after the bounty on his head, Vash must contend with the dangerously destructive Nebraska Brothers - while saving the very same villagers who are bent on bringing him in!

Things get complicated when the gang gets tangled up in the drama surrounding a runaway dancing girl and the son of a caravan owner.

Meryl files a report the Bernadelli Insurance Company, recounting the many exploits, misadventures, and lunatic moments of Vash the Stampede.

A flashback offers a glimpse into the distant past of Vash the Stampede, his brother, Millions Knives, and the enigmatic Rem Saverem.

The greatest battle of Vash the Stampede’s life arrives as he faces-off against Millions Knives. One brother wants to destroy mankind. One brother must stop him at any cost.