When Mike and then Liz contract a certain sexually transmitted condition, Mike blames the assumed originator Euan. The irritating malady hampers both Mike and Liz's anniversary dinner and Euan's date with a friend from college.

Euan's quest to find a steady girlfriend lands him Ginger, an artist who Mike believes is taking Euan for all he's worth. Meanwhile, Liz proves to Mike that her revealing clothing makes him uncomfortable.

In dire need of a job he actually enjoys, Mike seeks advice from a decidedly unreliable career counselor. Euan, meanwhile, concentrates his efforts on trying to win over their new neighbor, a B-movie actress.

When Euan's date, Lindsey, announces to everyone that she wants Euan to deflower her when she turns 18 at midnight, Euan, Mike, Chau, Status and Liz flashback to their own first sexual encounters.