Searching Mushiyori City, Yusuke's team was quickly steered to the hospital, where a trap awaited. There they encounter the Doctor, a human with immense psychic powers, super strength, feels no pain, and has infected the entire hospital with a deadly virus. To save his friends, will Yusuke be forced to destroy the wretched creature?

As Yusuke continues his chase of Sensui, the unbelievable Sniper confronts Yusuke. As Genkai and the rest of the team follow, can Yusuke escape Sniper's endless barrage, reach Sensui and save Kuwabara... not to mention, the entire human race?

Kurama's anger has sentenced Toguro to an eternity of suffering, forever chasing his foiled revenge. But the tunnel to Demon World is opening. Can Yusuke's team still save the human race? Only a dramatic showdown between the past and present Spirit Detectives will reveal the truth!