The Martini family moves to Poggio Fiorito, a residential area on the outskirts of Rome. Lele has to face all the problems that the transfer entails. Luckily, her sister-in-law Alice is there to help him.

The new maid of the family, Cetinka, causes confusion: as soon as she is hired, some money disappears, and suspicions fall on her. But will she really be like this? And are we sure that the woman is from Poland?

Alberto, Lele's only nephew, runs away from home and takes refuge in the Martini house, as his parents are divorcing. Meanwhile Nonno Libero, to put aside some money, starts selling musical cushions.

Maria is about to have a birthday and asks her father to be able to celebrate alone with her friends, Lele agrees but is sorry. At the same time Maria gets her period and the first to know about it is Rebby.

Alice and Giulio, Lele's best friend, are worried because the doctor hasn't seen women for years and so they decide to arrange an appointment for him with a girl named Irene, a 35-year-old doctor.

Lele's salary is not enough to support family expenses. So his ex-father-in-law finds him a job in a private clinic where plastic surgery is performed. Will it suit him?

Barbara arrives at the ASL, a young intern who courts Lele. While this is happening, Giulio is admitted to the hospital after a heart attack; Will Lele's timely intervention be able to save his life?

Ciccio is struggling with his first love and would like to ask his father for advice, but Lele is currently thinking of something else. In fact, the trial regarding the accident in which his wife Elena died has begun.

Due to a sudden flood in his home, Giulio finds temporary refuge at the Martini house. Lele is obviously happy to lend a hand to her best friend... but up to a certain point.

Alice convinces Lele to enroll with her in a tango course, the spark strikes between the two and they realize that they are attracted to each other, but just at that moment Sergio, Alice's ex, arrives.

Grandpa Libero, attracted by the piano teacher Maritè, asks her to give some piano lessons, and Alberto and his friends start smoking against Lele's advice.

Laura, a colleague from the local health authority, has problems with her ex-husband, and so Lele decides to help her, posing as her boyfriend. But only Lele seems to be pretending: Laura really seems to feel something towards the doctor.

An abnormal mole appears on Alice's skin. He will have to undergo surgery, and he will only want Lele by his side. This will trigger the strong jealousy of her current boyfriend, Sergio.

The relationship between Sergio and Alice is getting serious. Lele convinces herself to openly declare herself to her sister-in-law but the results will not be as hoped for.

Sergio and Alice set the date for their wedding. At the Martini house no one is happy that Alice is getting married, and they are right: one evening, in fact, having returned home drunk, Sergio savagely beats Alice.

Alice's wedding is annulled: fortunately the woman has actually seen who was in front of her. So she, upset, moves to the Martini house. Meanwhile, an old flame of Lele's arrives at the clinic.

Nonno Libero argues with the in-laws who would like to enroll Maria in a very exclusive private school. While she doesn't look good, she's pretty focused on her crush on a boy at her school.

Irene's reappearance creates a lot of confusion in Lele's mind to the point of not realizing how unhappy Alice is. In the meantime, grandfather Libero's romantic relationship seems to go on.

Lele organizes a reunion lasting an entire weekend at the Martini house with all her youth friends, offering them room and board, but over the years her friends seem to have changed considerably.

Ciccio is sad because he didn't bring a good report card to his father, who scolded him. She meets Gus, a child who lives and works at the circus, and then decides to go with him and run away from home.

Great jealousies gravitate in the air: Irene is angry with Lele because no female doctor at the ASL is able to resist his advances, Maria is instead grappling with her first disappointment in love.

TV series - Not all courtships are welcome. Nonno Libero tries to contain Marite's advances, while Alice has to curb the editor's 'attentions'. A surprise ending to Irene's birthday party.

Lele finally manages to spend a night of passion with Irene but things get complicated when he decides to introduce her to his family. Meanwhile, Giulio is dealing with a serious problem.

Lele's relationship with Irene has begun, but not everyone welcomes it. Especially Mary. Uncle Spartacus' arrival from America is welcomed as an event to be celebrated, but the visit hides a bitter surprise.

Maria who continues to hate Irene hoping that Aunt Alice will fall in love with her father, because they seem like a perfect match to her. Meanwhile, Cettina refuses a proposal to live together from her boyfriend.

Lele discovers that Irene hid from him that she had won a scholarship to Boston. She also does not intend to follow him to Milan to the wedding of friends. It is there that Alice and Lele find themselves alone in Lele's room.

Ciccio wears a hat lent to him by his girlfriend Susy, but the hat is full of lice and the whole family is infected. Meanwhile, Alice and Giulio organize an evening for four, but it will be a disaster.

Lele and Irene argue after the latter discovers that Lele spent the night with Alice during their wedding in Milan; Irene is involved in a road accident, while Nonno Libero's motorbike is stolen.

A new doctor arrives at the ASL: Doctor Oscar Nobili. One day a shot is heard from the newcomer's room, it is a man who is trying to commit suicide in front of Oscar. Lele will discover a secret.

The Martini family goes to Venice to visit Nonno Libero's brother. After visiting the city, the Martinis go their separate ways. From this moment on the trip turns out to be full of unexpected events hidden just around the corner.

While Lele and Irene visit the stalls of the neighborhood party where even Libero, Giulio and Giacinto sell modern objects, the Martini house catches fire.

Lele is very worried: the insurance, which has expired, does not cover the costs for the renovation of the burnt house and Ciccio confesses that he caused the fire by playing with firecrackers.

Alberto hopes that his mother has finally found the man of her life. Unfortunately the woman has decided to resume the affair with her ex-husband, who comes to a strong clash with her son. Alberto will still remain at the Martini house.

Irene, due to the expiry of her contract with the Asl of Rome, has to ask for a transfer. Lele tries to save their relationship and asks her if she wants to marry him.

Grandpa Nicola finally returns from Brazil, and Nonna Enrica decides to peek into his suitcase, discovering a beautiful necklace. The bad surprise, however, is that her husband returned three days before her: he lied to her!

Ciccio suspects a relationship between his father Lele and his friend Susi's mother. Meanwhile Alice is becoming famous, but her career seems to compromise her family affections.

While Lele and Irene spend the weekend in Bologna, the new neighbors arrive, with whom Ciccio has some problems. Meanwhile Cettina argues with Alberto because of his snobbish friends.

At the Martini house, it seems that a maniac is pursuing Cettina, in reality it is just a misunderstanding. Meanwhile, Alessia Merz shows up at the local health authority and seems interested in Lele.

A group of children from an institution for orphans arrive at the polyclinic for vaccinations. Among them is Robertino, a kid with Down syndrome who mistakes Lele for Santa Claus and asks him for a new bus for the Institute as a Christmas gift.

Nonno Libero has organized a show with Orietta Berti, but it would appear to be a scam. Alice and Irene will also have to work on Christmas Eve, and the magic of Christmas is struggling to reach the Martini house.

Ciccio is looking for a girlfriend for Nonno Libero in a magazine for lonely hearts. Ricky, Jessica's boyfriend, ends up in a coma after a car accident. Maria, on the other hand, is invited by a boy she likes.

On the radio where Alice works there is a column dedicated to health. Lele and Alice are convinced that the presenter is a charlatan, and even the ASL are starting to worry about the success of the show.

Alice gives Maria tickets for the Backstreet Boys concert, but a worried Lele doesn't want to give her permission. Luckily grandfather Libero intervenes!

Giacinto is fired, and it's up to Cettina to resolve the situation. Meanwhile Jessica and Lele go to Ricky who has awakened, but there is a nasty surprise lurking.

Ciccio steals from grandfather Libero's wallet and together with his friend Filiberto skips school and goes to the mall. But there the two are threatened by other kids, who force them to give them the money.

Lele finds a pregnancy test in Irene's locker, and hopes for the arrival of a child. But things are not like that, and indeed Irene was taken to a clinic in Milan. This changes everything on the table.

Maria heard the news of Leonardo Di Caprio's arrival in Rome to shoot a film and goes to Cinecittà, where she meets Johnny, the bodyguard, and develops a crush on him. Meanwhile Giulio decides to leave for Africa.

Alice was seen in the company of Tiberio Timperi and Lele gets jealous. Meanwhile, Giorgi discovers that he has kidney failure and everyone at the ASL is worried, while Lele and Irene continue to argue.

The Martini family relaxes in the countryside, where Maria meets a boy who invites her to a party. But the situation takes a turn for the worse: the boy shows too much insistence, until he becomes violent. But someone is ready to intervene.

Grandma Enrica returns from Ponza with some news, she has fallen in love with the owner of a fruit and vegetable supermarket that Alice doesn't see kindly. Meanwhile Lele decides to buy a ring.

Alice meets François, a doctor friend of Giulio's who is in charge of finding families who can take in African children for some time and decides to leave with him to make a report. And Lele?

Lele and Alice spend the evening together to celebrate their departure, but he is unable to confess what he feels. But when she finds out from François that Alice is in love with him, she decides it's time to come out.

Lele is anxious to see Alice again after her declaration at the airport, but a letter sent by her seems to cast shadows on the future of their relationship. What will happen?

Lele goes to the airport for Alice's arrival, but in her place arrives a woman who Alice met in Africa and to whom she gave the ticket. There is still a wait for the two lovers, but what will happen when the time comes?

Lele decides to give Alice the ring she had bought some time before, but it seems to have disappeared into thin air. Meanwhile, the story between Cettina and Giacinto seems definitively over.

Lele's birthday but the whole family pretends to forget about it to throw him a party. Meanwhile, the doctor's relationship with Alice is being kept secret, but how long will they be able to live in hiding?

Libero would like Lele to marry Alice, but his son does not feel ready yet. Er Pasticca, a friend of Alberto's, asks him to deliver some pills, but these end up in Annuccia's hands.

Alice has organized a romantic weekend with Lele, but the latter has to go to a conference in Turin. Among her colleagues there will also be an old friend of Lele of whom Alice is terribly jealous.

Cettina asks Giacinto to meet to clarify their situation, but the latter does not appear as he is the victim of a stabbing. Cettina can't know it, and imagines that the ex didn't show up deliberately.

While at Alice's house, Lele learns that her fiancée has been receiving phone calls for several weeks from a manic admirer, who doesn't seem to want to stop there.

Libero participates in a competition to win one evening at dinner with a singer, introducing himself as They Killed Spider-Man. The grandfather takes home the victory: Max Pezzali arrives at the Martini house.

While the Martini are on the radio, Lele receives a phone call announcing that Alberto has had a car accident. Everyone rushes to the hospital and discovers a very different reality.

Alice spends more and more time at Casa Martini. Alberto feels responsible for the accident that left his friend Adriano disabled, but thanks to his uncle's help he will find the strength to go and see him in the hospital.

Lele and Alice have decided to get married and are looking for a place for their honeymoon together. Everyone helps them find it, but everyone has her own opinion and in the end they decide to go it alone.

While preparations are underway for Lele and Alice's wedding, the latter is assailed by doubts. Lele finds a letter in which the woman says she is confused and wants to think away from him.

A group of girls dressed as odalisques arrive at Lele's bachelor party, including one in particular who is very close to Lele. Alice catches him in the act, but are we sure she saw us right?

The preparations for the wedding seem to never end. The small village where Alice spent her holidays as a child was chosen for the wedding ceremony. But there is no shortage of setbacks.

Lele and Alice are finally married, but while they are leaving for their honeymoon, the woman has a miscarriage, not even knowing she is pregnant. Plans change dramatically.

Maria and Reby come up with a really good idea: to have their friends play in the garage! Will they be able to get Lele's permission? Giacinto thinks of leaving his job as a security guard and opening a shop. Will Cettina allow it?

"Pisticca" apologizes to Adriano, but will he be able to make up for it? To escape Carmelo, a very insistent suitor, Enrica takes refuge in the Martini house. What will Lele and Alice come up with to stay alone for a while?

Alice feels bad all the time and already a few people tell her that the symptoms are all there and that she could be pregnant. Instead, Lele fears that it is something serious.

Alice does the ultrasound and discovers that she is expecting twins. Lele and Alice go home to announce the news to the others, when a phone call arrives letting Nonno Libero know that his friend Fausto is in the hospital.

Nonno Libero packs his suitcase and leaves home due to the constant quarrels of his two children, who find him in a rest home. Until he learns that he has been appointed condominium administrator.

Nilde wants Lele to enter the delivery room, but the next day Lele wakes up late and arrives at the hospital when her sister has already given birth, by surprise, to a black baby.

Alice and Lele announce the sex of the unborn children to the family: they will be a boy and a girl, but the happiness is not shared by the whole family because Annuccia becomes jealous.

Alice is very anxious about the arrival of the twins, and fills the family with advice and reading manuals on birth. Not to mention the contractions that terrify her and force the couple to rush to the hospital every night.

Alice tries to help Maria who is facing a particular moment in her life: Roberto has asked her to make love with him, but the girl doesn't feel ready for such an important step, even if telling her is difficult.

A great job opportunity for Alice is ruined when contractions begin. Meanwhile Lele is in the hospital where Giorgi died from a post-operative rejection... Will he be able to arrive in time for the birth of the twins?

Lele leaves for Australia while Alice, who will soon join her husband, is in Brazil. Maria meets Guido at the University, a brilliant doctor who is looking for a house and will be hired by the new director at the Local Health Authority.

Maria is very fascinated by Guido, but it seems that the doctor is not interested in her at all. Meanwhile Ciccio, after a prank that risked ending in tragedy, tries to escape from Lele in Australia.

Enrica notices the growing understanding between Maria and Guido and puts a "flea in the ear" of Nonno Libero who begins to worry. Meanwhile, everyone begins to discover that Alberto has not even given an exam at the University.

Nonno Libero does not want anything to happen between Guido and Maria and does everything to keep them away. Meanwhile Alberto is depressed and sleeps in the garage to be alone. He will need the help of the family to get him out of the dark evil.

Cettina sets out to look for Giacinto, discovering a bitter truth. Maria, due to a painful episode, no longer wants to take medical tests. Will Guido be able to convince her otherwise?

Nilde is forced to close the restaurant due to poisoning and notices that Guido is the one who signed the complaint. Alberto, by improvising a nighttime radio episode, manages to get hired on a permanent basis.

A new nutritionist, Carlotta, arrives at the ASL. With her obsessive and detached behavior it is not possible to win her sympathy, and misunderstandings and disagreements arise between her and Guido. Until something brings them back together.

Guido tries to make friends with Carlotta, but the obstacle to overcome is the girl's phobia of physical contact, a difficult difficulty to overcome. Meanwhile, Maria is increasingly jealous of Guido.

Nonno Libero meets Antoinette, the nanny of one of Annuccia's classmates; the child is strangely too calm and Antoinette doesn't understand why, so Nonno Libero invites her to take him to the ASL, to have him examined by Guido.

A mysterious statue found in the garden divides the family. Guido tries to help Carlotta solve her problem, but the situation soon escalates to near disaster.

Carlotta confesses to Guido that she is in love with him, sending him into a crisis because he cannot understand his feelings for Maria. The birthday dinner with the latter, however, skips due to a hiccup.

Maria is happy to have met Gianluca, a charming lawyer, who courts her like a real princess. Meanwhile, some kids enter Ciccio's school at night and break the pipes to skip questions and homework.

Gianluca surprises Maria by taking her to lunch on a boat on the Tiber, which carries a flag with Maria written on it. Meanwhile, Guido has gotten together with Carlotta, and everything seems to be going well... or not?

Carlotta suggests that Guido move in together, the doctor accepts. Meanwhile Maria, having broken off the story with Gianluca, has started working as a volunteer in a recovery center for drug addicts.

Maria is preparing for an exam and is very nervous and Nonno Libero thinks it is Gianluca's fault. Guido and Carlotta continue their story, even if the failed cohabitation puts the relationship to the test.

Nonno Libero picks up the news on the news that a young blonde student has been arrested in Fiumicino together with Gianluca for drug dealing. Thinking it's Maria, he feels bad and suffers a heart attack.

Meanwhile, Guido has problems with Carlotta, tired of seeing her boyfriend totally taken by the Martini family. Maria sees Gianluca in front of her house who tells her he wants to escape to avoid trial.

Guido and Carlotta are increasingly in crisis and during a dinner they argue again. Guido goes to a friend's house who introduces him to two girls and the following morning, the doctor wakes up drunk next to one of the two.

Maria is angry with Guido and disappointed because he betrayed Carlotta. A course on self-esteem is held at the ASL and thanks to it the doctors are able to bring out their problems, especially Carlotta.

Guido and Maria go to get Annuccia from the biopark, but the little girl gets lost. Because of this, Guido does not show up for the appointment with Carlotta, but in the meantime Maria and the doctor finally kiss.

After the kiss at the biopark, Guido understands that he has feelings for Maria but she would like him to leave Carlotta first who, in the meantime, seems increasingly tied to Marcello and not just for work.

Maria is tired of waiting for Guido and decides to go out and have fun with Reby. During a night outing she is stopped by the police and her car is withdrawn. Who's gonna get her out of that mess?

Maria and Guido go to the beach to be alone and when they return home, covered in sand, Libero understands that the two have spent the afternoon together. However, due to an error, Guido is suspended from the ASL.

Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that in reality everyone already knew. Meanwhile, Guido makes home visits and the patients show up at the Martini house because they only want him.

The story between Guido and Maria falls apart due to a misunderstanding. Even grandfather Libero is furious with the boy, he can't understand that in reality it's not his fault. Guido then decides to make a video to explain everything.

Having lost all hope of getting Maria back, Guido asks for an immediate transfer to Milan and outside the ASL he says goodbye to Marcello and Carlotta. During the journey to the church, Maria realizes that she wants Guido and she runs to the station.

There is a lot of news in the Martini house: Maria and Guido have been engaged for two years and Guido goes back and forth between Rome and Milan, Ciccio still plays rugby and is engaged to an English girl named Emma and…

Nonno Libero is summoned to school because Annuccia has done a decidedly strange essay on the family. Maria rents a house for her and Guido, but discovers that, for now, he is forced to stay in Milan.

Meanwhile, Guido is sad because he has to stay another two years in Milan and doesn't know how to tell Maria, who in the meantime is doing an internship at the ASL. On the way to Milan he has an accident.

Maria misses Guido very much and is thinking of continuing the university in Milan at least until she graduates. Guido meanwhile is trying in every way to get transferred, but it seems that there is no hope.

Cettina and Torello's house is now completed, but Cettina will find some nasty surprises. Maria and Guido have decided to move in together and to keep them from going far Cettina will find an unexpected solution.

The family members decide to give Guido and Maria a whirlpool and a Bohemian crystal chandelier, but the boys get angry because they would like to be the ones to furnish the house. The first quarrels arise.

Between friends and family, at Guido and Maria's house you can't find a moment of peace, and this certainly doesn't do the couple any good. Nonno Libero, on the other hand, due to a series of misunderstandings, thinks that Ciccio is on drugs.

Grandpa Nicola is back in style, but the reality is very different from what he wants to make it seem. He invites Maria on a cruise and she, who initially refuses, finally understands that her grandfather has only her family affection left.

Between friends and family, at Guido and Maria's house you can't find a moment of peace, and this certainly doesn't do the couple any good. Nonno Libero, on the other hand, due to a series of misunderstandings, thinks that Ciccio is on drugs.

Cettina asks Torello to let her nephew Rosalbo join the company, but one night they hear him plotting against them on the phone. The two decide to make life impossible.

Cettina doesn't know how to tell Torello that in reality she isn't pregnant because he is showering her with attention, organizing everything for the future baby. During an ultrasound, she steals footage showing triplets to play along.

Libero is worried about Olindo, an old friend of his who has been missing for days. He learns that he is in a hospice he can neither talk to him nor know how he is. Libero then asks Guido to make an inspection.

Maria has returned from the cruise and Guido immediately fills her with affection, so much so that the two are caught by the entire Martini family immersed in the whirlpool. Meanwhile, Cettina has a decidedly "horror" experience.

Guido is anxious because he has to present the project for the family hospital, but Maria forgets the interviews with the ASL. But the troubles aren't over: the scooter doesn't work, it's a race against time.

Reby tells the Martinis that she is getting married to a Japanese designer she met the week before. Maria is not convinced, knowing the fast falling in love with her friend, but this time it seems serious.

Guido finds a pregnancy test, actually belonging to Reby and, frightened by something he feels is bigger than him, he runs away and leaves himself a note for Maria. The girl, with no news from her for two days, is heartbroken.

A man very similar to grandfather Libero has been wandering around the Martini house for a few days and for grandfather trouble begins: everyone begins to think that he is seriously getting old and does not remember things.

After a check-up recommended by Enrica, grandfather Libero learned that his values ​​are not good and that open heart surgery may be necessary.

Libero writes a letter and delivers it to Enrica with the task of sending it to Lele in case he dies, then both go to the town hall to sign the marriage papers and ask to get married as soon as possible.

The ASL risks closing and all the doctors organize a protest sit-in, which will prove to be useless. Guido, on the other hand, decides to make a request to return to Milan, given that staying in Rome no longer makes sense for him.

While the ASL is being dismantled, the doctors decide to carry out all the visits on the list for free. Meanwhile Guido is nervous and has an argument with Maria. Furthermore, he will be responsible for definitively closing the ASL.

Franco decides to take Maria to a farmhouse, but the same evening the girl, after reading a note from Guido, realizes she is confused and luckily the only thing she is sure of is that she doesn't love Franco.

Guido is looking for funding for the family hospital and decides to organize a heart game to raise funds and at the same time proposes a donation to the bank.

After spending the night with Guido, Maria runs away and confides in Reby, telling her friend what happened the night before. But she also tells her that she's confused that she doesn't know what she's feeling right now.

Guido and Maria are back together and are stronger and happier than before, but he wishes Maria would not leave for Nigeria. He also has a really important proposal in store.

After three years of absence, Lele returns to the Martini house, finding a situation that is not a little indifferent. Thanks to the help of Nonno Libero, Lele will finally be able to become a full-fledged family man again.