As the new season begins, Cat Black is conflicted about her full term pregnancy, because the father (Nick Kroll) is 6 years old and has advanced aging disease; the doctors remember Lola who still seems to be dead; Chief has more than professional feelings for the new administrator; Glenn cures cancer.

Cat goes into labor with Little Nicky's baby. Little Nicky's advanced aging disease causes him to take on the tendencies of an old man as the disease begins to kill him. Lola Spratt returns from the hospital to explain that she faked her death, but everyone believes she is a ghost. Blake Downs returns to the hospital, following the failure of his private practice/spin-off. New doctor Valerie Flame takes over narrating duties on the show for Cat Black when complications occur in the birth of she and Nicky's child.