Frasier vows revenge after a pair of radio "shock jocks" embarrass him in a series of on-air pranks.

After Frasier and Niles' New Year's plans fall through, they take a riotous road trip with Martin in his Winnebago.

Frasier continues to be conflicted about whether he truly wants to be with Lana instead of Claire. He consults his family, but a chance encounter at the airport steers him toward making a decision. Unfortunately, he may be too late.

Kenny tells Frasier and Roz that some recent research into KACL listeners shows that Frasier's average listener is an older gentleman who keeps the radio on for company. He suggests Frasier reach out to the youth.

To quell a feud between Frasier and an upstairs antagonist, Martin and the neighbor's mother feign a romance.

Cette dixième saison s'articule autour d'une histoire en trois parties où Niles est confronté à sa mortalité lorsqu'il subit un pontage cardiaque, un événement qui a de curieuses conséquences sur son mariage avec Daphne. Plus tard, la nouvelle analyste financière de KACL, Julia Wilcox, vient s'ajouter à la liste des femmes sans lesquelles Frasier ne peut pas vivre. Dans le dernier épisode, Roz s'apprête à démissionner de son poste de productrice pour Frasier et à quitter Seattle pour toujours.

KACL organizes a bike-a-thon to raise money for AIDS research. Frasier plans to just make a financial donation, but is goaded into participating after Julia announces her intention to take part. Daphne suggests that she and Niles also enter the event.

Frasier learns that Dr. Phil McGraw is in town for a special. The two are old friends, but Frasier is angry at Phil for supposedly swindling him out of $200 in a poker game. He reluctantly agrees to take the star-struck Roz to the set to see him.

Niles is questioned by the police because he loaned Maris the murder weapon--an antique crossbow--for use in a play. Maris insists that she acted in self-defense. She continually calls Niles from jail, leaving Daphne extremely angry.

Weight loss challenges KACL, enrolled in a pound-shedding contest that pits Frasier against a taunting nemesis who bullied him in high school.

Courting unnerves Frasier, whose wooing of a winsome matchmaker is constantly interrupted by her disarming beau, a dedicated environmentalist who's also quite cosmopolitan.