Monroe and Rosalee are finally off on their honeymoon, but that doesn't mean trouble isn't stirring in Portland. Nick and Hank are called to a shocking homicide at an abandoned residence many Portland locals think is haunted, even the survivors swear a ghost committed the murder. Meanwhile, on the heels of Juliette’s startling revelation Captain Renard seeks the help of a mystical woman from his past.

Nick and Hank are called to the scene when three Wesen go out on a hunt at a local dump and get more than they bargained for when two turn up dead after they encounter the mythical Rat King. Meanwhile, a very badly wounded Trubel is taken to the hospital and Nick finally meets Meisner.

Following a brutal attack in the woods, Nick and Hank stumble upon a terrifying Wesen disease that may be the inspiration for the modern-day werewolf myth. Meanwhile, Adalind is offered an uneasy alliance that may help her get back what she wants most. Elsewhere, Eve's investigation uncovers a surprising revelation.

Nick and Hank join Wu to investigate a bizarre murder in a local park. Elsewhere, Capt. Renard continues to deal with a ghost from his past. Meanwhile, Monroe and Rosalee visit the doctor to see if Diana's premonition is true. Back at the loft, Adalind finds a very weak Eve in the tunnels and mysterious drawings scrawled on the walls.