On the eve of the Smallville High School Prom, stuck-up candidate for Prom Queen Dawn Stiles is pulled into a coma when she is involved in a car crash into a ravine filled with dozens of chunks of kryptonite. While her body lies in a coma, Dawn finds her spirit allowed to possess the bodies of others, where she can continue her quest to become Prom Queen. As a result, Martha, her body possessed by Dawn, flirts with Clark and asks him to the Prom, Lana attempts to electrocute the ex-boyfriend who dumped Dawn, Lois goes all-out to ensure she and Clark go to Prom together, and Chloe attempts to set fire to the school on Prom night.

A krypto-mutant, Gabriel, hacks into missile codes and prepares to eliminate krypto-mutants in Smallville once and for all. A powerless Clark confronts him and is shot, and only Jor-El can save him.

Chloe is possessed by the spirit of a young girl whose body is sealed in the Talon's walls, and goes searching for the girl's killer while Clark and Lois try to track her down.

Clark and Chloe pursue a plant creature that uses male humans to recreate, one which has taken Jimmy Olsen as its next human breeding ground. Meanwhile, Oliver Queen asks a reluctant Lois to be his date at a charity ball held by Lex.

After being shot while stopping a carjacking, the Green Arrow begins acting strangely. Chloe and Clark investigate and find Oliver is taking a super drug that while healing his wound, has some dangerous side effects.

Clark is in his barn one moment... and the next finds himself in a psychiatric hospital where he discovers he's been suffering from delusions that he came from another planet and has super-powers.

Kara takes to life in Smallville by getting a job at the Talon, and entering the Miss Sweet Corn Pageant as a contestant, overruling Clark's objections. However, Lex takes an interest in her and three of the other contestants discover she has super-powers and decide to use her to steal a valuable time capsule.

A mysterious man who claims to be a product of Lex's latest project plants a bomb on Chloe and uses her to force Lois to get the truth from Lex.

While Clark seeks out Brainiac to force him to fulfill his side of their bargain and restore Lana, Chloe and Jimmy go up against the government.