Gus and Vaun wage an attack on Palmer as Eph struggles to connect with Zack. Councilwoman Justine Faraldo vows to bring her extermination policies to the other boroughs.

Eph and Nora finally see their lethal virus in action. Fet takes the security of Red Hook into his own hands while Dutch and Setrakian set off for Staten Island to question Fitzwilliam, Palmer's former body guard.

Eph changes his appearance to leave the city while Nora is left as the reluctant parent for Zack. Dutch and Nora make a deal with Justine to secure Fet's release from jail.

Eph must protect Zack against a surprise intruder into Red Hook. Gus convinces the Guptas to make a difficult choice. Fet and Setrakian set out to acquire the Lumen.

Justine takes drastic measures to counter a surprise invasion. Nora and Fet perform a useful mission while Eph and Setrakian face off against an old foe.