Maritza goes all out on the hunt for Michael after Dade dies, as does Bosco, who's intent on finding his brother before Maritza does; Faith calls Maritza a liar in front of Swersky when Maritza claims that she saw Michael shoot Dade; Fred is still angry about Faith repartnering with Bosco, and refuses to discuss it; Breene revisits the house and urges the paramedics to talk to professionals or to each other to help deal with the stress of the shootout; looking to collect the reward for information leading to Dade's killer, Anthony tells Maritza where Michael can be found after she lies to him about her relationship with Bosco; Bosco finds Michael moments before Maritza, and his brother claims that he's innocent and that a drug dealer named Spider was Dade's murderer; Spider comes out with machine guns blazing when Maritza, Sully, Ty, Faith and Bosco attempt to arrest him, and a ferocious gun battle ensues; Maritza agrees to work with Michael as an informant after Bosco pleads for his

Wary of Lester Martin, the high-priced lawyer his father has found for Mikey and the deal he's attempting to broker, Bosco warns his brother to stay away from Maritza, but Mikey decides to disregard his brother's advice and makes a deal to become her informant; for good measure, Bosco threatens to kill Maritza if anything happens to Mikey; Sully teases Ty about his budding relationship with Sasha; Faith and Bosco strike a deal with Laura, who also has no love lost for Maritza, to protect Mikey by helping her nab the drug dealers before Maritza gets to them; J.D. offers Kim a ride home, but stops off first at a rave that both Anti-Crime and Narcotics have staked out, thanks to information Mikey gave them; when some bad ecstasy begins to take a rapid toll, the paramedics call for backup, which prompts Maritza and her detail to storm the building; after an arsonist lobs a Molotov cocktail into the crowded building, Faith and Bosco give chase and capture him, while the firefighters rescue

The Boscorelli family suffers a tragic loss at the hands of Donald Mann, who blames Bosco, Faith and Maritza for the death of his son in a high-speed chase; the Yokas family heads off in different directions; the Martin family splits apart into separate jail cells for the parents, and a return home for Rebecca to the mother from whom she was stolen as an infant; the paramedic family at the 55 gets a new member, Grace Foster, which makes no one involved very happy.

Faith begs Fred to return home, but he refuses for a reason that infuriates his wife; Bosco turns a cold shoulder to Maritza's attempts to offer her condolences; Carlos is spectacularly unsuccessful in his attempts to hit on Grace; on the day of his son's funeral, Donald Mann exacts his revenge with the help of a dirty cop by planting bombs designed to kill the police officers he holds responsible for the death of his son; after Mann's lieutenants force a man to crash a car carrying a live bomb into the funeral home where Mikey's wake is being held, Grace takes charge and goes out of protocol to save Rose's life, and Dr. Fields later swears to have her job for it; Kim's decision not to enter the funeral home while the bomb is still live stems not from cowardice, but from maternal instincts; when Mann discovers that some of his intended targets survived the bombings, he sends machine-gun wielding minions into the hospital to finish off the job.

After a fierce gun battle and some hand-to-hand combat, Mann's gunmen are finally subdued by the members of the 55 in the E.R., but not before Orland is murdered and Bosco is critically injured; after Kim heroically puts herself in the line of fire to save Holly and a little girl, she realizes that her days as a paramedic are over, and that her future lies in being a wife to Jimmy and a mother to their children; Grace and Dr. Fields patch up their differences and come to an understanding about her out-of-protocol field procedures; Maritza uncovers the traitor in their midst, who leads her to Mann; Faith steps over the line to avenge her partner.