A guest is murdered on-air on a controversial talk show. Meanwhile Logan and Briscoe have a new boss, Lt. Anita Van Buren, and Stone gets a new collague; the police and district attorney attempt to prosecute the show's abrasive host.
McCoy finds that his career is on the line when his former female assistant and ex lover accuses him of forging evidence that helped put an innocent man in prison.
After a child in a day-care center dies of a virus, Briscoe and Curtis try to find the source of the infection, leading to a case involving an extramarital affair, embezzlement and a drug manufacturer.