When eight-year-old Jenna Wechsler dies as a result of a building explosion, Green and Cassady follow the trail of evidence to Rosalie Schaffner, the owner's ex-wife. McCoy and Rubirosa pursue Rosalie Schaffner despite a lack of concrete evidence, but the case takes a turn when Rubirosa finds a piece of evidence that points them in a new direction.

The investigation into a pair of missing pants leads to the murder of a young lawyer. Lupo and Green soon turn their suspicions to a businessman who works for a shady multinational corporation called SavingsMart.

Detectives Lupo and Bernard investigate a serial killer who targets homeless men and discover that a copycat may be at work.