Elizabeth is determined to continue to hold a human trafficking conference in Kyrgyzstan despite the inappropriate actions by a U.S. ambassador. Also, Elizabeth and Henry worry about Alison when she keeps coming home from college.

Elizabeth flies to Fashion Week in Milan to face off against the Chinese Foreign Minister over an anti-sweatshop treaty in the aftermath of a tragedy. Also, Daisy struggles with feelings of fear and pessimism over her baby’s future, under the threat of rising nationalism in the wake of the attack on the White House.

As Elizabeth prepares to leave the state department and announce her run for president, terrorists attack the United Nations delegation in Geneva that is there to sign the climate migration treaty.