Twenty years after a mysterious death rocks Wallace University, another murder takes place.

When anti-Kappa Dean Cathy Munsch decrees that sorority pledging must be open to all students, and not just the school’s silver-spooned elite, all hell is about to break loose, as a devil-clad killer begins wreaking havoc across the campus.

Chanel finds a new project in Hester, Chanel #3 confesses a secret and Grace and Zayday uncover a surprising connection between two fellow students. Meanwhile, Denise sets her sights on one of the Kappas, and Dean Munsch appoints a new Wallace University mascot as Chad and Earl Grey lead the fraternity on a witch hunt for the Red Devil.

Grace enlists Chanel’s help to learn more about KKT’s past, and ends up realizing she might not be so different from her nemesis after all. Dean Munsch goes “psycho” when she becomes the latest target of the Red Devils. Meanwhile, Denise becomes the new house mother of Kappa House and a shocking figure from the past returns.

After the horror-filled events of Thanksgiving, the Chanels decide to celebrate their favorite holiday -- Black Friday, but the Red Devil has plans to stop their shopping spree. When the Kappas conclude that Dean Munsch is the killer, they set a plan in motion to stop her once and for all. Meanwhile, Denise lands yet another job, Chad offers Pete a chance to join the Dickie Dollar Scholars and someone confesses to being the murderer.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Years after the murderous events at Kappa House, Dean Munsch purchases an abandoned hospital under the guise of fixing the healthcare system in America. After recruiting surgeons, Dr. Brock Holt and Dr. Cassidy Cascade, as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels to join the ranks at the teaching hospital. Meanwhile, secrets from the hospital’s past begin to reveal themselves and a new killer surfaces.

Determined to find out who the killer is, Dean Munsch, Denise and the Chanels question Hester, as well as the sole survivor (guest star Alec Mapa) of the Halloween massacre. Chad accuses Brock of being the killer and makes a shocking proposal to Chanel. Meanwhile, a new patient with an outrageous disorder (guest star Cheri Oteri) leads Chanel #3 and Cassidy to grow closer, and another victim crashes a celebration.

The frightful events of Halloween force Dean Munsch to notify authorities of murders at the Institute, which leads to a surprising influx of new patients. Meanwhile,Chanel is tired of doing dirty work, so she concocts a plan that entails recruiting new patients to join the Chanels. Later, Zayday and Chanel #5 visit a person with ties to the hospital's past; and a new patient's problems have the staff going a bit mad.

In an effort to secure positive press for the hospital, Dean Munsch pitches a risky surgery to Dr. Holt, whose hand begins expressing more of a wild and dangerous personality than ever before. Meanwhile, Chanel #3 forces Cassidy to undergo a psych test to find the root of his condition with surprising results, and Nurse Hoffel sets a devious plan in motion.

The Chanels are overwhelmed when their TV idol, Dr. Scarlett Lovin, visits the C.U.R.E. Institute. Meanwhile, Hester calls a Green Meanie summit as the killer(s) put their final kill plan into effect.

The Green Meanie sets its final plan for revenge in motion as Hester makes a bold move to secure her future, and Brock performs a dangerous surgery to save Dean Munsch's life.