Chicago Med braces for an influx of trauma patients when a pre-dawn pileup finds the hospital in full scramble mode. As a result of the storm and emergencies, supplies become limited and Goodwin, Dr. Manning and Dr. Halstead must deal with making an impossible decision. Meanwhile, Dr. Choi handles a severely burned patient who has one final request and Dr. Charles deals with an agitated patient.

Dr. Halstead gets an unplanned visit from the CPD while Ethan is skeptical of a woman who is experiencing chronic pain. Natalie tends to a cancer patient whose brother has strong feelings on why he is refusing to lend his assistance

Will and Natalie prepare for their big day, but an unsuspecting Will soon finds himself sidetracked. Dr. Charles disagrees with Goodwin on how to best handle a patient's treatment while Dr. Choi and April are on their own when a pregnant woman delivers. Dr. Rhodes finds himself operating on a patient that is of great importance to Det. Halstead.