After discovering that a patient's family might have been abusive, Dr. Choi and April contemplate calling child services. Dr. Manning and Dr. Halstead struggle to see eye to eye in guiding a family who is dealing with their premature baby. Dr. Rhodes is persuaded into preforming a risky surgery on Dr. Bekker's mentor. Meanwhile, Dr. Reese joins Dr. Charles on a visit to the Cook County jail.

Upon hearing news of a pregnant teen, Dr. Manning and Dr. Choi venture to a homeless encampment to help deliver a baby under dire circumstances. Dr. Rhodes and Dr. Bekker argue about the best way to treat a young boy with a chronic disease. Dr. Halstead and April are put in an uncomfortable situation when they find out their patient is a pedophile. Goodwin and Maggie have to deal with a lawsuit against the hospital. Dr. Charles learns of important news pertaining to Dr. Reese's father.

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to best handle the boy's parents. Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.