Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

As Maggie deals with her own trauma, she steps in to help a mother in need. Dean continues to stir the pot with more than one doctor. A patient comes to Med needing immediate treatment, but doesn't want it from them.

An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie's secretive behavior begins to draw the attention of Dr. Marcel and Dr. Halstead.

Third-year med students begin their rotation in the ED and Maggie keeps a careful eye on one of them. Natalie, whose mom's health takes another decline, tries to cover up how she broke the rules to treat her.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.

Scott suspects his patient may be a drug dealer. Halstead must decide how to spend his whistleblower settlement. Charles and Taylor help a patient who believes she's infested with parasites. Marcel and Blake are paired with an arrogant surgeon.