Д-р Роудс и д-р Занети се надпреварват с времето, за да спасят пострадал пожарникар, когато се оказва, че случай на бореща се за живота си жена е много сходен с тези на други пациенти.

Д-р Роудс и д-р Чой имат несъгласия относно молбата на умиращ пациент.

Д-р Манинг и д-р Чарлс попадат на 16-годишен пациент, който се оплаква от стомашни болки и отказва да приема лекарства, а в това време д-р Халстед лекува свой стар съученик.

Лекарите от Чикаго преживяват различни промени.

Инцидент на чикагския маратон налага спешната намеса на медицинския персонал.

Детската любов на Шарън пристига в болницата, докато Холстед се опитва да въведе в ред финансите си.

Д-р Холстед и д-р Манинг се занимават с двама враждуващи братя, които са докарани заедно и единият се оказва крайно нуждаещ се от бъбрек.

Д-р Рийс е повикан да помогне на проблемен тийнейджър в психиатрична клиника, докато д-р Манинг се опитва да даде съвет на родители, чиято дъщеря в безсъзнание се оказва бременна.

Д-р Чой и д-р Холстед са изправени пред нуждата от решение как да лекуват пациент със симптоми на удар, д-р Манинг лекува младо момче, което е паднало в реката, а д-р Роудс преглежда човека, който е спасил пациента на д-р Манинг от удавяне.

Хакер спира компютърната система в болницата с искане на откуп, което принуждава лекарите да диагностицират пациентите без помощта на технологиите.

Нещата стават прекалено лични за д-р Холстед, когато неговият отчужден баща е приет за лечение в болницата против волята си.

Д-р Роудс се бори за живота на майка, която отчаяно иска да помогне на умиращата си дъщеря, докато д-р Чарлз моли Сара да извърши психологическа оценка на дъщеря му Робин.

Д-р Роудс отправя предизвикателство към д-р Чарлз и други от болничния персонал във връзка с определянето на подходящото лечение на Робин.

В Чикагската болница пристига нов напорист лекар, който влиза в съперничество с д-р Роудс.

The doctors of Chicago Med take their opinions to the extreme as they try to bring justice to the perpetrator in the shooting of Dr. Charles. Dr. Halstead and Dr. Manning work on a heart-wrenching case that forces them to examine their own matters of the heart. Though Robin’s brain tumor was removed and she is discharged from the rehabilitation center, Dr. Rhodes remains on edge that her problems are not quite resolved. Meanwhile, Rhodes gets blindsided by his colleague Dr. Bekkar, Maggie sticks up for a patient and Dr. Choi and April try to navigate their new working relationship.

Dr. Manning goes to extremely measures to help a fearful pregnant woman whose baby is severely underdeveloped. April is angered by Dr. Choi when he uses their personal relationship as leverage to convince a patient of a risky procedure. As Dr. Rhodes attempts to balance his personal and professional life, it appears the stress of his current situation may have caused him to make a huge mistake.

When Goodwin receives financial complaints from the hospital board, she is forced to implement new guidelines that cause headaches for the doctors. Dr. Rhodes and Ava continue to compete in the operating room, while Dr. Charles and Dr. Reese are surprised when they treat a man who has a peculiar theory about his sickness. Dr. Manning and Dr. Cho can't figure out what is wrong with a young girl, leading them to look to a questionable source for answers.

Dr. Charles learns a troubling fact about the man who shot him. Dr. Rhodes and Dr. Bekker come to an agreement during a complicated surgery. Will and Natalie are trapped by legal ethics when an unfaithful husband refuses to tell his wife about his inconclusive Zika test. Meanwhile, April and Noah discover working together isn't always easy while Goodwin continues to argue with the board over hospital costs after an avoidable patient death.

When a young woman with HIV symptoms and no insurance refuses to take the test, Goodwin and Dr. Choi attempt to treat her without taking a toll on the hospital's resources. Natalie and Will try to diagnose a young girl with increasing paralysis. Noah deals with his first death as a resident and takes it upon himself to inform the family. Sarah continues to avoid work as her fear over the hospital's security increases.

Ethan attempts to diagnose a man with no symptoms while Sarah's paranoia goes to the extreme when she uses pepper spray on an aggressive patient. Will treats a young couple willing to sacrifice anything in order to have a baby. Meanwhile, Natalie must inform a woman that she was sterilized as a young girl without knowledge, and Goodwin and Maggie devise a way to persuade paramedics to bring in more patients.

After witnessing a drive-by shooting and hitting her head, Dr. Manning struggles with the aftermath of a head injury. Complicating matters, she and Dr. Halstead deal with a teenage patient and her overbearing older husband, who might not be looking out for his young wife's best interests. Dr. Rhodes finds himself in a unique situation when he learns alarming information about the woman he went on a date with. Maggie is surprised to discover some unexpected things about the man she has been seeing. Dr. Charles is frustrated when Dr. Reese disobeys his orders and puts herself at risk.

After a neighbor is stabbed, Dr. Choi enlists the help of April to figure out who is the real cause of the incident. Dr. Bekker and Dr. Rhodes expertise is put to the test when Noah misdiagnoses a patient. Dr. Charles is put in an uncomfortable position when Dr. Reese's estranged father comes to him as a patient without her knowledge. Meanwhile, Dr. Manning rushes to save a baby with whooping cough.

Dr. Halstead and Dr. Manning are at odds over the care of a vegetative man; Dr. Rhodes goes behind Dr. Bekker's back to get his patient at the top of the transplant list; a woman in the waiting room falls asleep and won't wake up.

After a baby is abducted from Med, Goodwin enlists the help of Dr. Charles and Dr. Reese to find the suspect. Due to the lockdown, Dr. Rhodes must figure out a way to get into the operating room to help perform open-heart surgery. Dr. Manning and Dr. Halstead disagree on the right treatment for a patient.

After taking the lead on a surgery, Dr. Bekker feels the heat after something goes wrong. Dr. Manning and Dr. Charles are faced with a tough decision concerning the gender of a 9-year-old girl. April and Dr. Reese rush to find the son of a dying patient. Goodwin's godson is admitted to the hospital.

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to best handle the boy's parents. Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.

Bekker takes drastic action to keep Rhodes from leaving Med for good. Meanwhile, Halstead questions Manning's feelings about their upcoming wedding, Ethan receives shocking news about his sister, and Dr. Charles mourns a loss.

A power outage at Med puts multiple patients at risk and tests the skills of the staff and their enthusiastic med students; Natalie returns following her traumatic brain injury; Ethan and April wonder if a family is in their future.

Dr. Choi and Dr. Marcel don't see eye-to-eye over the treatment of a patient's chronic pain and rumors start to circulate about Maggie. Dr. Manning works to help a young boy, but her treatment suggestions are challenged by the parents who believe in only using holistic remedies.

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

Maggie gets unsettling news about a new friend and breaks protocol to support him. One of the doctors from the Med family is rushed into emergency surgery after a violent assault. A social media influencer lets his users vote on medical advice, forcing Dr. Charles to make a decision.

Dr. Halstead's world is thrown into turmoil when a former patient resurfaces. April has a secret she considers confessing to Ethan. Dr. Charles tries to maintain his focus during a difficult time.

After a major accident at O'Hare, the E.D. is concerned one of their own is in mortal danger. Will's proposal for a safe injection site goes to the board for consideration. Natalie and Goodwin become concerned for Gwen.

Two brothers in critical condition are rushed into the hospital by their parents, leaving Dr. Choi, April and Dr. Charles to tend to their care and left to piece together what actually transpired. Dr. Manning becomes suspicious of a new mother entering the E.D. Dr. Halstead’s tireless activities at the safe injection site start to take a toll on his work.

Dr. Charles and Dr. Manning treat a patient who is fully invested in pretending to be someone other than himself. Noah begins to doubt his abilities as a doctor. Dr. Marcel and Dr. Choi are faced with a tough ethical decision. Dr. Halstead puts his faith in an addict.

Dr. Halstead finds continued success in his trial. Dr. Charles' daughter, Anna, receives life-changing news. Noah finds himself in a situation not even April can fix.

Halstead relies on Marcel and Med's newly donated OR 2.0 to save his patient. Charles helps an elderly, confused patient who's mourning the loss of his high school sweetheart. As their wedding day approaches, Choi and April run into some roadblocks.