Dr. Choi helps a patient with chronic pain find a solution. Dr. Halstead considers a new path. Dr. Charles and Anna bond over a scary situation.

Crockett deals with a patient who ends up having more in common with him than he thinks. Will and Ethan clash over a pregnant patient with an irregular heartbeat.

Crockett worries he made a surgical error when a recent transplant patient comes in with complications. Carol is once again in distress. Will and Natalie must take action to right their wrong.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.

The effects of the supply chain shortages continue to impact the ED when Taylor's drug dealer reappears. One of the victims of the recent train crash needs a transplant.

Marcel and Charles treat Lieu's gym buddy. Maggie and Halstead help a robbery-homicide suspect. Asher and Archer use Med's new opiate abuse AI program.