Dylan and Charles treat patients suffering from Glass Child Syndrome and misdiagnosed ADHD. Crockett has to navigate hospital politics when he cares for the daughter of a transplant surgeon. Will and Stevie must lay egos aside to help save an elderly patient.

Crockett and Blake clash with Randall when a famous alcoholic football player needs a liver transplant. Dylan is reluctantly reunited with old friends when their son breaks his arm. Stevie and Charles work together when a patient falls ill after back-alley plastic surgery.

Rival gangs bring their war to Med. Halstead and Charles work with a brain cancer patient who's refusing treatment. Tensions run high in the OR when a patient's transplanted uterus fails.

Dylan and Ethan treat a patient shot during a drug raid. Charles and Vanessa work together to properly diagnose a motivational speaker. Will and Hannah must turn to Crockett for help with a patient who's pregnant.