Archer and Asher clash over a patient with close ties to Goodwin. After a patient is shot during a home invasion, Scott and Marcel help with the investigation. Maggie and Halstead work to protect a patient who is in the country illegally.

Maggie's budding romance takes flight. After a woman's shocking suicide attempt, Charles searches for answers. Asher works to diagnose a patient who is new to the city and appears with mysterious symptoms.

Ripley and Charles treat a high-risk prisoner who may have dementia. Archer and Sean clash when a resident from Margo's facility lands in the E.D. Marcel receives shocking news.