In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try to save the survivors. Charles and Med's new fellow, Cuevas, help a paranoid patient.

Charles and Cuevas clash over the treatment of a paranoid patient. Choi treats a pregnant patient from Asher's past. Marcel and Taylor help a man who needs a risky neurosurgery.

The effects of the supply chain shortages continue to impact the ED when Taylor's drug dealer reappears. One of the victims of the recent train crash needs a transplant.