After a police officer is murdered, Patterson unlocks a disturbing tattoo that appears to have predicted his killing, and the team chases a violent clue trail to stop further attacks. Mayfair reveals secrets from her past to Weller, seriously testing their relationship.

In order to capture a dangerous international criminal, Jane and Weller are forced to collaborate with the only person he will meet: their former target, Rich DotCom. Jane must decide whether to risk hurting Weller by executing a morally questionable order from Oscar.

When a school shooting breaks out during the investigation of a tattoo, the team splits up to take down the shooter. Mayfair copes with some issues from her past.

After an abandoned baby is found with a tattoo identical to one of Jane's, the team races to piece together the child's identity and save dozens of infants. A furious Jane confronts Oscar about the outcome of his secret missions.