Sutton's mind rells as wives two and three ask him for a very great personal and professional favor and wife one chacks in for a serious medical problem. Kate anxiously awaits news of who will be appointed as the new head of surgery. Dr. Shutt performs delicate surgery on a wealthy quadriplegic who cannot be anesthetized, and whose beautiful fiance attracts Nyland's attention.

Tommy places a bid to buy out the hospital with the intention of firing Kate as soon as the deal goes through; as Valerie continues her affair with Danny, Jack lets Danny know that he's aware of their relationship; Elizabeth is readmitted after Andy beats her again, and Andy takes his revenge when Dennis attempts to help his sister escape the cycle of spousal abuse; a mysterious biohazard accompanies a patient admitted to the E.R., and immediately begins to fell the staff; after Kate pleads the hospital's case, Jack agrees to counter Tommy's offer, but only if Phillip fires Danny; Kate and Tommy threaten to expose each other's secrets; after Diane's work for the last two years is called into question and her grant money is suspended, she decides to go to Africa to do research with a colleague; Tommy courts Aaron's support; feeling under-appreciated and ill-respected, Camille resigns; realizing that Tommy will stop at nothing to destroy her, a desperate Kate flees with their daughter an

Austin sprays a subpoena server with mace, inspiring his fellow servers to wage war on the hospital. Hancock tries to counsel a woman in her late forties whose health is severely threatened by her pregnancy but who refuses to let the baby be delivered early. Kronk finally returns to Chicago, dressed in Masai garb, and tries to reconnect with Diane.

A hit-and-run victim escapes serious injury but her infant twins face a desperate crisis. Hancock faces testifying in court against his brother-in-law. Patient Linda Fortin's heart continues to grow weaker as her pregnancy progresses, endangering herself and her baby.