The city of San Jose is rocked by a massive earthquake that puts the staff of St. Bonaventure Hospital on high alert as they race to assess the damage and account for the safety of their colleagues and friends. Meanwhile, Dr. Neil Melendez and Dr. Aaron Glassman are attending a charity event when their lives are threatened by the earthquake.

The staff of St. Bonaventure Hospital works against time and their own personal safety to save the lives of those around them.

Dr. Morgan Reznik and Dr. Shaun Murphy's pregnant patient with twins is having pain and they are forced to grapple with a decision no one wants to make. Meanwhile, Shaun asks Lea to move back in despite her reservations

When the hospital is hit with a cyberattack threatening to shut down life-saving machines, Lea rises to the challenge and looks to outsmart the hackers to prove herself. Meanwhile, the team treats an inspirational cancer survivor-turned-successful-philanthropist who harbors a dark secret.

Shaun confronts Salen about the many changes she has implemented since coming on at St. Bonaventure. Glassman is forced to accept his new role at the hospital.

Asher's views on the construct of marriage complicate his future with Jerome. Meanwhile, Asher also briefly revisits his religious past to aid a patient's conversion to Judaism for his fiancée.

Dr. Claire Browne returns from her work in Guatemala for a personal medical examination. Elsewhere, Dr. Glassman struggles to manage Hannah, who remains unresponsive to his attempts to help. Park seeks out the perfect last-minute wedding location.