9-year-old Sheldon Cooper is a once-in-a-generation mind capable of advanced mathematics and science but learns that isn’t always helpful growing up in East Texas, a land where church and football are king.

Sheldon struggles with newfound popularity after utilizing statistics to help the football team.

George Sr. strikes a deal with Sheldon to tutor Georgie when poor grades threaten to keep him from playing football

When Sheldon moves to Dallas to attend a school for gifted children, the family struggles to cope with his absence.

A video game takes over Sheldon and Connie’s life. George Sr. is jealous when Georgie bonds with Herschel at the auto shop.

Sheldon studies his family for a psychology project. Thanksgiving dinner turns into a family fight when George Sr. is offered a job in Oklahoma.

When Sheldon has to spend a few days in the hospital, he turns into the world’s worst patient. Also, Missy gets a taste of what life would be like without her twin.

Sheldon uses his new friendship with the school bully to boss Georgie around. Also, Missy steals Connie's makeup for picture day.

Sheldon moves in with Dr. Sturgis for the weekend to see what his life will be like in college. Also, a lonely Mary tries to bond with the other Coopers during Sheldon's absence.

Georgie is thrilled when Veronica stays at the Coopers' house for a few days. Also, Connie and Dr. Sturgis celebrate their one-year anniversary.

The Coopers help Pastor Jeff through a rough patch in his marriage. Also, Sheldon pressures church members for donations when Mary takes him to work for a day.

Sheldon invites the entire school to a party for the Nobel Prize announcements. Also, Connie learns more about Dr. Sturgis' past, and Georgie's desire for cable TV leads to a standoff between him and George Sr.

After Dr. Sturgis experiences a nervous breakdown, Mary worries Sheldon is headed down a similar path. Also, Georgie discovers he has a knack for sales.

Without Dr. Sturgis’ university class, Sheldon must find a new way to stay academically challenged. Also, Mary helps Pastor Jeff avoid temptation with his girlfriend.

A church carnival leads Missy to try out for the baseball team. Also, Connie struggles after her breakup with Dr. Sturgis.

The University makes George Sr. a lucrative job offer in the hopes of recruiting Sheldon. Also, Georgie gets a job working for Connie's new boyfriend, and Mary is determined to rid her home of greed.

Sheldon fakes being sick to avoid a swim test at school. Also, Dr. Sturgis spies on Connie's new boyfriend.

Sheldon learns to listen when an emotional Paige struggles with her parents’ divorce. George Sr. is furious when Georgie tries to buy his way out of chores.

When George Sr. accidentally lands the school librarian in the hospital, the Cooper family must nurse her back to health. Connie gives Georgie relationship advice.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Connie is furious when she learns Dale fired Georgie.

Dale and Connie work out relationship issues while playing Dungeons and Dragons with Sheldon and Missy. Also, Mary and George take a trip with Coach Wilkins and his wife, and Georgie freaks out when his girlfriend thinks she's pregnant.

Connie takes matters into her own hands when Sheldon's philosophy teacher, Professor Ericson, sends him into a tailspin. Also, George Sr. learns Georgie has been cutting class.

Sheldon is caught in a moral dilemma when offered a bootleg copy of a computer game he can't afford. Also, Mary and Connie take Brenda out for girls' night while George Sr. and the guys watch Billy, and Missy asks Georgie to take her and Marcus on a secret date.

Sheldon finds himself at odds with Paige once again when she considers enrolling at East Texas Tech. Also, Mary seeks June's advice when looking for a change.

Sheldon encourages Missy to question the Bible. Also, Connie is determined to catch George Sr. in a lie, and Mary helps Pastor Jeff search for a youth pastor.

Sheldon tries to convince Dr. Sturgis to return to the university. Also, Georgie upsets the family when he makes a life-changing decision.

Sheldon and Dr. Linkletter struggle to solve an equation. Also, Georgie has a solution for Connie's business woes, and George Sr. gives advice on Missy's love life.

Sheldon makes friends with his dorm neighbors; George Sr. learns his job is in jeopardy.

Connie's gambling room is a success, and Sheldon dips his toe in the stock market. Also, Missy starts a business.

Sheldon and Missy learn about Georgie's pregnancy, and the whole family promises to keep it a secret.

As the church congregation gossips about Georgie, Missy stands up for her brother, and Sheldon is distracted by the family drama.

Sheldon struggles to cope with the first signs of puberty. Also, Mary and George Sr. hunt for new jobs, and Georgie and Meemaw take a business trip across the border.

George Sr. is asked to help with the football team. Also, Mandy discovers Georgie and Connie's secret business.

Sheldon considers dropping out of college to focus on building his database. Also, George Sr. is frustrated when someone else gets credit for his football wins.

Missy steps up, Mary has a surprise for George, and Sheldon finds his dorm occupied.

George Sr. is worried that Mary wants another baby and gets a vasectomy behind her back. Meanwhile, Drs. Linkletter and Sturgis go to Sheldon for science tutoring.

George Sr. gets an exciting job offer, and Sheldon prepares for his move to California.

Sheldon leaves East Texas for the California Institute of Technology following the death of his father, George Cooper Sr.