As his clinical begins, Devon treats his first patient with a revolutionary medical fluid that doesn’t go as planned. Meanwhile, an overdosed John Doe is rushed to Chastain, leading Conrad straight into a much bigger scandal than he expected. Then, a shocking secret regarding Cade’s past is discovered.

When Conrad confronts a pharmacy owner about fraudulent prescriptions being filled under his name, the situation takes a dangerous turn; the ER is sent into chaos when a street racing accident results in multiple severe injuries.

Conrad and Cade work with a Medicare patient who sheds some light of prescription fraud. Leela works herself to the brink of exhaustion.