Harley Quinn is fed up being the Joker’s sidekick and strikes out on her own – determined to become the criminal Queenpin of Gotham City.

In search of a nemesis, Harley goes after Batman, but ends up with an adolescent Robin, making her the laughing stock of the criminal underworld.

When Harley suffers a paralyzing identity crisis, her crew must enter Harley’s mind to free her with the help of Dr. Psycho’s telepathic powers.

Harley recruits her friend and mentor Queen of Fables to help her steal a force field from STAR Labs, to steal a weather-changing machine, so she can impress the Legion of Doom. Meanwhile, Poison Ivy dates Kite Man.

Harley thinks the Legion of Doom is behind Ivy's capture and the tree monsters currently ravaging Gotham. But it's a trap!

Bruce Wayne awakens from his coma to Gotham in chaos.

When Harley and Ivy spot a seemingly sane Joker, they debate whether people can change at their core, revisiting a flashback about Harleen Quinzel's first day at Arkham Asylum.

Harley crashes Ivy's wedding to stop Gordon and his officers from interrupting the nuptials.

After fleeing the wedding, Harley and Ivy go on an "Eat Bang Kill" tour that leads them to a secret project Ivy abandoned years ago.

When Frank goes missing, Harley and Ivy follow clues that lead them to a highly unconventional party alongside Gotham’s elite, including Commissioner Gordon – who is hungry for campaign donations.

When an inadvertent plant zombie apocalypse breaks out in Gotham, Harley fights to save the city, while Ivy embraces her inner supervillain.