Max and Helen settle happily into their new life in London. Dr. Fuentes takes over as medical director with disastrous effects. Bloom helps a patient who thinks he’s cursed. Iggy develops a plan to get his psych patients gainfully employed.

Helen takes the reins at NHS Hampstead Hospital while Max gets creative to help a patient in need. Reynolds reaches a decision about Dr. Malvo. Iggy and Bloom help their patients understand the underlying cause of their stress. Dr. Wilder employs more unconventional techniques.

As the team gathers to mourn the loss of someone dear, Max and Helen realize the extent to which New Amsterdam has changed since they left. Bloom struggles with a big decision while Reynolds decides to take his concerns for his patients to a new level. Dr. Fuentes once again reminds the New Amsterdam team who is in control.

Max formulates a bold plan to help New Amsterdam before it’s too late. Reynolds and Dr. Fuentes fight over the best way to handle a risky surgery. Dr. Wilder asks Dr. Castries for help with a patient with terminal cancer. Iggy helps a father and son deal with vastly different views on a shared trauma.

The New Amsterdam team goes out for a night of karaoke and drinking, but must face the consequences at work the next day. Iggy helps a mysterious patient confront a past trauma. Reynolds and Dr Malvo discuss their future. Leyla gives Lauren some bad news.

The New Amsterdam team continues to deal with the consequences of their big night out. Max and Helen discuss options for their future. Martin finally learns Iggy's secret. Bloom helps Leyla avoid a life-changing situation. Reynolds and Dr. Malvo define their relationship going forward.

Max orchestrates a plan to get Dr. Fuentes terminated from New Amsterdam once and for all. Helen confronts her medical complication. Iggy helps two patients deal with a breakup, which forces him to consider his own marriage. Bloom and Dr. Castries reach an understanding.