A village within Daigo's domain is being terrorized by a ghoul that dwells in a nearby lake. Tahomaru, accompanied by his aides Hyogo and Mutsu, volunteers to exterminate the ghoul.

Kagemitsu, who offered up his own son to the demons. Hyakkimaru, who is trying to get back the body parts that were taken from him. As if drawn together by fate, they face each other.

Dororo has been captured by Itachi and is being taken to the cape where Hibukuro supposedly hid the money. As Itachi and his men look for boats to get across to the cape, they are approached by a one-armed boy named Shiranui.

While traveling along a mountain path in search of a demon, Dororo and Hyakkimaru encounter a young man named Dice-spot Saburota. The man says that he too is hunting the demon, and they set off to exterminate it together.

Daigo Kagemitsu continues to prepare for war with the neighboring land of Asakura. Upon receiving word that Hyakkimaru is approaching his domain, Kagemitsu sends Tahomaru to dispose of him.

Hyakkimaru comes face to face with Tahomaru, Mutsu and Hyogo, who have been possessed by the power of demons. Dororo, Lady Nui and Biwamaru hurry to the scene, where they witness a ferocious battle that will determine the future of the land of Daigo.

Daigo's castle is engulfed in flames. Within, two brothers by blood are at the mercy of fate. Dororo, Jukai and Lady Nui also head for the castle, each with their own thoughts weighing down upon their hearts. For a life that began with a silenced cry, where will the path of destiny lead?