A traumatic assault. A hidden romance. A signed consent form. Secrets both shared and unspoken test Kate and Tully’s friendship over the years.

Tully and Kate weather health issues and romantic entanglements, from a college dalliance to a steamy encounter that leaves an ex hot under the collar.

Vows are made and hearts broken as Kate navigates her long-strained relationship with her brother, and Tully grapples with compromise and commitment.

Over holidays past and present, relationships shift — and truths are spoken — as Tully and Kate reshape their expectations for what the future holds.

Trying times bring Kate and Tully together as they contend with an overbearing grandma, a pesky new intern and an ex-husband in distress.

A teen magazine. A political investigation. A secret message. Shocking revelations lead to major questions for Sean, Tully and Kate.

While celebrating their own freedom on Independence Day, Tully and Kate learn time and again that relying on each other may not be so bad after all.

For the first time in decades, Kate and Tully experience a year apart — but can they handle major life events without each other?

Kate has often felt invisible next to Tully through the years. But amid major changes, Kate realizes she may need her best friend by her side.

From bra-stuffing to breastfeeding, Kate experiences several bumps in the road on her journey from a self-conscious teen to a first-time mother.

Kate and Johnny's loved ones gather for two very different celebrations. Tully gets tangled in a romantic dilemma, and Kate feels the weight of a secret.

Tully, Johnny and Marah try to find ways of coping after Kate's revelation. In the 1980s, Johnny wrestles with another piece of overwhelming news.

On a special day for the Mularkey family, Tully reflects on decades of work, love, grief and joy alongside her best friend. Kate faces the unknown.