South African Airways Flight 295 starts filling with smoke over the Indian Ocean. A fire has erupted in the rear main level cargo area; the pilots successfully open the doors in flight to clear the smoke from the aircraft, however it crashes with no survivors.

On 7 December 1987, Pacific Southwest Airlines Flight 1771, on a flight to San Francisco, crashes at the speed of sound on a mountainside in rural San Luis Obispo County, California. All 43 people on board are killed. Investigators found that passenger David Burke, a former USAir employee, took a gun on board the aircraft and shot the pilots in a murder-suicide plot to kill his former supervisor (who was also a passenger on board) after being fired from his job days earlier. USAir was in the process of merging with PSA at the time of the crash.

On 21 February 2008, Santa Bárbara Airlines Flight 518, en route from Mérida, Venezuela, to Caracas, veers off course and flies into the side of a mountain shortly after takeoff. All 46 passengers and crew members on board die. Investigators determined that the aircraft took off with inoperative navigation equipment due to the pilots' failure to do their pre-flight checklist.