Mel engages in a tense family reunion when she and her disapproving sister race against the clock to save their brother Edison after he’s abducted. Also, as the team unravels the motivation behind Edison’s kidnapping, Mel grapples with the fallout of her argument with McCall about training Delilah.

When the mother of a patient dying of a rare brain disease holds a hospital hostage in an attempt to get her daughter a lifesaving surgery, McCall races to resolve the situation peacefully while dealing with pushback from government forces.

When a man claiming to have lost his memory wakes up behind a dumpster with a gun in his hand, McCall and the team follow a trail of clues to help uncover his whereabouts the night before.

After an operative kills all but one of the employees at a marine biology research group, McCall and the team join forces with Colton Fisk when they discover a connection between the murders and a secret CIA program he was involved in.

When a Venezuelan migrant is accused of murdering a prominent congresswoman whom he and his wife were staying with, McCall and the team work to uncover whether or not he was involved. Aunt Vi tries to look after a student who seems to be experiencing distress at home.

Aunt Vi enlists the help of McCall and the team when she realizes her masseuse is a victim of domestic abuse. Also, McCall trains Dee on situational awareness and Dante goes against orders by chasing after the man who shot his friend Manny.

The team is put into harm's way when McCall's former CIA colleague is found alive and sets her sights on revenge by attempting to abduct Dante, Harry and Mel. Also, Aunt Vi and Delilah must act quickly to de-escalate a hostage situation of their own when a robber targets a bodega. Third season finale.