Drama médico que refleja las complejas vidas de los donantes de órganos, los pacientes que los reciben y los cirujanos en uno de los mejores hospitales del país, donde cada segundo que pasa es de vital importancia.

Dr. Nathaniel Grant is a pioneering organ-transplant surgeon who takes risks that other doctors would not in order to save the lives of his patients. He works closely with his ex-wife, Kate Armstrong, an organ-donor coordinator with whom he has a volatile relationship. Grant's arrogance and willingness to perform risky procedures causes him to butt heads with the hospital administration. But his main focus is on his intense relationship with his job and his patients, often at the expense of his family.