Loey, Louie og J.J. er barndomsvenner, og som voksne har de svært ved at finde deres plads i livet. De drømmer om at åbne en bar sammen, men de mangler i så udpræget grad cool cash. De ved dog, at mafiabossen Big Tony gemmer penge i sit hus. De planlægger et kup mod ham, men Big Tony har helt andre planer...

New York, The Bronx, 1980. Two Italian boys Joey Esposito and Louie Mazerino jump to the defence of a smaller Puerto Rican boy, J.J. Lopez, when J.J. is threatened by six schoolyard bullies. The three boys soon become best friends, and they always look out for each other. However, their innocence is shattered when they witness Big Tony, the local Mob boss kill a man. The three boys vow to each other to keep it a secret. Fifteen years later, the three boys, now in their late twenties are still the best of friends and still living in The Bronx. They dream of opening their own bar. Desperate to better themselves, Joey devises a scheme to steal money from Big Tony and open their own Joint.