John Drew Barrymore (Los Angeles, Califòrnia, 4 de juny de 1932 - Los Angeles, Califòrnia, 29 de novembre de 2004) va ser un actor de cinema nord-americà i membre de la família d'actors Barrymore, que incloïa el seu pare, John Barrymore, i els germans del seu pare, Lionel i Ethel. Va ser pare de quatre fills, entre ells l'actor John Blyth Barrymore i l'actriu Drew Barrymore.

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John Drew Barrymore (born John Blyth Barrymore; June 4, 1932 – November 29, 2004) was an American film and television actor and member of the Barrymore family of actors, which included his father, John Barrymore, and his father's siblings, Lionel and Ethel. He was the father of four children, including actor John Blyth Barrymore and actress Drew Barrymore. Diana Barrymore was his half-sister from his father's second marriage.

Barrymore was born in Los Angeles, California to John Barrymore (born John Sidney Blyth) and his third wife, actress Dolores Costello. His parents separated when he was 18 months old, and he rarely saw his father afterward.

He made his film debut at 17, billed as John Barrymore Jr.