The young Hua Fu Sheng is ignorant of the world, but he is obsessed with medicine. His unconventional medical practice makes the people in the city love and fear him. He was mistaken for being a murderer because of the deaths of a hundred doctors, and the clues in the letter left by his master seemed to point to the mysterious "Book from Heaven".

It just so happened that Wen Jue, the daughter of Liangzhou's City Lord, and Gu Tian, the successor of a hundred operas, were also involved, and the three of them went to Liangzhou to investigate together. Wen Jue borrowed the power of the City Lord's mansion to protect Hua Fu Sheng from opening a medical clinic in Liangzhou, and Gu Tian assisted in gathering information with his eloquent tongue.