Adaptation of the novel by Anne Tyler.

Since her husband's death after only six years of marriage, Rebecca has single-handedly raised his ever-challenging and now adult daughters, Nono, Biddy, and Patch, as well as one of her own, Min Foo. Rebecca also inherited her husband's uncle, 99-year-old Poppy, a crotchety old man whose total focus is his upcoming 100th birthday. A party planner by trade, Rebecca is always cheerful and upbeat, but even after many, many years, she's still not really sure about her standing in this bizarre family. As she questions how her life might have been different if she hadn't jilted her former boyfriend Will for her husband, Rebecca decides to contact him. Seeing Will, now a divorced college professor living a structured life, only adds to Rebecca's dilemma. As her family life continues to swirl around her, Rebecca begins to understand how much they rely on her and, in their own unique way, truly appreciate her.

The story of two sisters – Beth and Rachel – who live very different lives. Rachel is a successful, driven fashion photographer in New York City. Beth who is develop mentally challenged, spends her days riding public buses. After the death of their father, Rachel comes home to be with her sister and the two literally butt heads.