A serial killer who preys on women haunts Chicago, and Kolchak comes to believe that the killer is in fact the original Jack the Ripper, a seemingly immortal killer who has killed women in many cities over the last century. The reporter must track the killer to the old house where he has taken up residence and put an end to his existence once and for all.

A bizarre alien presence invisibly sweeps through Chicago, killing a petty thief and a UFO nut. The alien or aliens have the strength of a hurricane, generate a massive electromagnetic field, steal lead and electronic equipment, and suck the bone marrow out of humans and animals alike. Kolchak must track the alien(s) from an electronics warehouse to an observatory to Lincoln Park and drive them off before they kill again. His camera seems to hold the key to the creatures' weakness, although initially Carl is wrong in guessing what the weakness is. Carl follows the aliens and manages to keep them from feeding on him before they depart once and for all.

Several Indian construction workers are killed during high-rise work on a new hospital. They leave the job, and the hospital is completed. However, a series of strange electrocutions continue to plague the hospital after its grand opening. Kolchak investigates and finds that a ""bear-god"" spirit, Matchemonedo, was resurrected from its burial spot beneath Lake Michigan by the hospital construction. Now the creature, which feeds on energy, is beginning to awaken. Kolchak must convince the hospital officials to re-refrigerate the ""bear-god"" and drive it back into hibernation before it awakens once and for all.