Cheyenne, Smitty and a woman they just rescued from an Indian attack are trapped by a band of desperados in their fortified mountain hideaway.

Trying to guide a lost wagon train, Cheyenne and Smitty tangle with a gang of cattle rustlers.

Cheyenne tries to help two prospectors in their search for a gold mine, but then they encounter renegade Indians who try to rob them.

Pursuing the bandits who killed a friend of theirs, Cheyenne and Smitty find that the gang has taken over an entire town and only the local padre has the courage to stand against them.

Cheyenne's previous acquaintance with a woman involves him in blackmail and nearly gets him killed.

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Guiding a cavalry troop through Indian territory, Cheyenne leads a mutiny to avoid a massacre.

A rancher named John Dembro gives shelter to Cheyenne who's been hurt in an ""incident"" on the adjoining ranch owned by Martin Storm. Both Dembro's teenaged daughter, Johnny, and her stepmother, Sheila, are anxious to treat Cheyenne's injuries and they become bitter rivals. Soon Dembro persuades the recovered Cheyenne to help him unite the other small ranchers to oppose Storm who maintains his authority through a hired ""gun"" named Swallow. Cheyenne kills Swallow in a shootout. Dembro becomes drunk in the ensuing celebration and dies in a fire, though Sheila could have saved him. Now free of her husband, Sheila makes a play for Cheyenne who spurns her. Hurt and angry, the increasingly-deranged Sheila has Cheyenne arrested, claiming he killed her husband. Sheila's deemed too crazy to give credible testimony so Cheyenne is freed but townspeople, believing Cheyenne's guilty, form a lynch mob, egged on by Storm. Johnny arrives on the scene and convinces the crowd of Cheyenne's innocence. Sto

Pat Keogh is a bank robber and killer who, when the episode begins, has just killed a man and Cheyenne has been accused by a group of vigilantes. Keogh rescues Cheyenne, admitting to him that he was the guilty party, and he cuts Cheyenne in on the bank robbery he's about to make in Red Rock with the help of two accomplices. Cheyenne meets a marshal friend who is trailing Keogh and enlists Cheyenne's help in stopping Keogh. Cheyenne foils the plot, but not after a lot of gunplay.

It's been five years since Ed McKeever's two daughters, Ruth and Jenny, were kidnapped by Chief Tanaka. A scout has just located the women and Cheyenne is assigned to lead the rescue mission of volunteers made up mostly of stockade prisoners from a nearby fort.

Cheyenne meets a sly Indian's test of courage to save a wagonload of white settlers.

In a Mexico wracked by political unrest, Cheyenne tangles with revolutionaries, a con man and a blonde pickpocket.

A small-town sheriff, whom Cheyenne admires, is hoodwinked by a woman.

Cheyenne's friend falls for a rancher's pretty daughter, but the rancher prefers Cheyenne as his son-in-law.