A forma como as vidas de três pessoas da mesma família são destruídas pelo vício e pela loucura: Harry e Marion são um casal que quer montar um pequeno negócio, mas sofrem com o vício das drogas, que os fará ir a extremos. Por sua vez, a mãe de Harry, Sara, sonha em ir ao seu programa de TV preferido. Mas quando é finalmente convidada começa, por vaidade, a tomar pílulas para emagrecer, ao ponto de o vício afectar a sua sanidade mental.
Joker Jackson e Noah Cullen são dois condenados presos um ao outro por uma corrente e que se odeiam. Depois de um acidente com o caminhão prisão que os transportava, eles fogem e são perseguidos pela polícia. Enquanto eles estão acorrentados, os dois são dependentes um do outro. Quando eles finalmente se livram de suas correntes, sua hostilidade já tinha se alterado para companheirismo e respeito.
Piper e Dodge são dois fugitivos da lei que têm apenas uma coisa em comum: as algemas que impedem que cada um siga seu caminho. Dodge era testa-de-ferro de mafiosos, contra os quais reuniu sem querer provas incriminadoras, e Piper um policial infiltrado no presídio. Para desvendar a trama, a dupla tem que permanecer viva.
O diretor John L. Sullivan quer fazer um filme chamado "E Aí, Meu Irmão, Cadê Você?", sobre problemas sociais. Quando seus produtores apontam que não entende nada do assunto, ele decide ir para as ruas para enfrentar de cara a pobreza e ver os problemas do povo, o que o levará a outros tipos de problemas.
Smith, a mob informer hiding out with the Witness Protection Program, decides to make a break for it and hide out in the Arizona desert. The Feds catch up with him and rescue him just before a group of hitmen can manage to silence him for good. In the course of getting Smith away from the mafia thugs, the pair of agents assigned to protect him turn onto an abandoned stretch of highway nicknamed 'Route 666' after the mysterious death of a prison chain gang. As the three continue on their way, they soon discover just what happened to the chain gang, and how the highway earned its name.
A World War I veteran’s dreams of becoming a master architect evaporate in the cold light of economic realities. Things get even worse when he’s falsely convicted of a crime and sent to work on a chain gang.
A wagon load of convicts on their way to prison is being escorted through the mountains by a cavalry troop. They are attacked by a bandit gang, and only a sergeant, his beautiful young daughter and an assortment of seven sadistic, murderous prisoners survive, and they are left without horses or a wagon. The sergeant must find a way to get his prisoners to their destination while protecting his daughter, watching out for the still pursuing bandits and trying to determine which one of the prisoners was the man who raped and murdered his wife.
Three criminals escape from prison and embark on a robbery spree across USA. Along the way, one of them falls in love while they plan a final heist before going their separate ways.
A fugitive from a chain gang becomes an oil-well firefighter and meets the man who framed him.
A poor cobbler's son enters a $25,000 cross-country hiking contest sponsored by the footwear company that has nearly bankrupted his father. He also has fallen in love with the girl on the company's billboards, the competition's daughter, and her sweet inspiration keeps him tramping along.
A prison-camp convict learns that his younger brother will soon be joining him behind bars.
When Morley has his own bank robbed, Tom tries to break it up. Mistaken for one of the gang, he is caught and sentenced to a chain gang. His girlfriend Peggy then sets out to prove his innocence.
A victim of circumstance, country and western musician Paul Ramsey finds himself on a Southern chain gang.
Mickey Mouse and several other characters are on a prison chain gang, guarded by Pegleg Pete. They break rocks for a while, then Mickey breaks out a harmonica and everyone starts making music and/or dancing. Soon there's a jail-break, and Mickey's on the run, tracked by bloodhounds (including his future pet, Pluto, in his first appearance). He falls off a cliff and right into a jail cell.
Former chain gang convict Ed Martin converts to Christianity in prison in 1944 and forms the HopeAglow Prison Ministries.
A shackled murderer and marijuana offender escape from a Georgia chain gang.
Four convicts escape from a chain gang. Shortly thereafter, changes are made at the prison, because a blue ribbon commission will be investigating conditions there. The changes include steak every day for dinner and stage shows for entertainment. After reading about this, the four escapees plead with the warden to take them back in. Or was this all a dream?