Izo is an assassin in the service of a Tosa lord and Imperial supporter. After killing dozens of the Shogun's men, Izo is captured and crucified. Instead of being extinguished, his rage propels him through the space-time continuum to present-day Tokyo. Here Izo transforms himself into a new, improved killing machine.

This film is shot in a continuous 78-minute take. The story takes place in a city ravaged by crisis, poverty and crime. The people who remained belong mostly to the low class, and they're struggling to survive through various criminal activities. One of the last prosperous citizens was murdered, and we're following a large cast of characters in their quest to find his corpse. One of the characters has different plans, but he gets involved in the quest against his will.