Ren Xinzheng, a professor at the University of Traditional Chinese Medicine, is dedicated to spreading Chinese medicine. He resigned to set up a traditional Chinese medicine inheritance class, hoping to train successors who can truly pass on the way of Chinese medicine. Unscrupulous Sun Toutou also accidentally joined the mentoring class, and he was at odds with Ren Xinzheng's son Ren Tianzhen, Yang Xiaohong, who had changed his career as a lawyer, Peng Shiyan, a pediatrician at a tertiary hospital, and Zhao Liquan, who wanted to become a famous doctor with the expectation of the whole village, and other students were also incompatible.

Heo Im is an oriental doctor, acknowledged as the best in acupuncture and moxibustion in Joseon. His success is blocked due to his low status.

After being found in 918, the kingdom of Goryeo faced a critical existential crisis when the powerful Yuan dynasty tried to subjugate them. In the fictional setting of this drama, a warrior living in the timeline of Goryeo meets a plastic surgeon living in the present day. The plastic surgeon gets kidnapped by the warrior who got an order from the king to find a doctor who can cure the fatally injured queen. The two individuals who were not meant to coexist are brought together to fight their way through the ordeals on the land of Goryeo. The warrior makes a promise that he will return her to her world, but a scheming royal advisor persuades the king to force the surgeon to stay as she can be useful to him. There, the surgeon falls in love with the warrior who is the leader of the royal guard. In this era of change and chaos, love that transcends time and space blooms.