American tourists at SpiritQuest Sanctuary, a medicine lodge in Peru, share their thoughts about the traditional medicine ayahuasca, and their motivations for drinking it. Don Howard Lawler, founder of SpiritQuest, describes ayahuasca and its beneficial effects, as do the filmmakers themselves.

Desperate to recover from his depression, Dave travels from his home in British Columbia, Canada to Peru in order to experience the healing effects of the sacred medicine ayahuasca. After Dave spends some time in the country, a Shipibo healer begins to teach him how to work with the medicine more deeply.

Michael Wiese documents his 10-day ayahuasca retreat at a lodge in the Peruvian Amazon.

Anthropologist and filmmaker João Meirinhos travels in Peruvian Amazonia to speak with healers who work with the plant medicine ayahuasca. The journey begins on the outskirts of Puerto Maldonado in southeastern Peru, and winds northward to Pucallpa and Iquitos.

Sachamama is a retreat lodge in Peruvian Amazonia. There, Francisco Montes leads ayahuasca ceremonies for tourists seeking insight and healing.