O desenho se passava em Nova York, onde o esnobe Peter Venkman, o manso Ray Stantz e o gênio Egon Spengler eram três cientistas do departamento de psicologia da Columbia University, que se dedicavam ao estudo de casos paranormais. Mas quando a subvenção terminou, eles foram despedidos. Assim, Venkman sugeriu que tivessem um negócio próprio, mas como não tinham dinheiro fizeram empréstimos, alugaram um prédio quase caindo aos pedaços e inauguraram ali uma exterminadora de fantasmas chamada "Ghostbusters". Para atender aos telefonemas contrataram como secretária, a irritante Janine Melnitz.
Martin Mystery has a passion for all things paranormal. When he's not at school, this teenage lover of supernatural ooze works undercover for a secret bureau specialising in mysterious phenomena. Together with his older stepsister Diana, Java (a massive caveman lost in time) and Billy (a small green hovering creature), he checks out weird wonders. Martin is always bursting with energy and seldom thinks before he leaps. Diana is his guardian angel – a straight-A student, she brings the brains to their missions. Seen a zombie, alien or ghost? Call Martin Mystery.
Jake Kong Jr. and Eddie Spencer Jr. are sons of the original Ghost Busters, and they work alongside Tracy the Gorilla (who also worked with their fathers). Together, they are dedicated to ridding the world of the evil ghost wizard Prime Evil and his cast of henchmen.
Based on the blockbuster films, this action-packed animated series starts a decade after the original Ghostbusters saved New York City from ghosts, goblins and ghouls. All the guys have left town, except Egon, now teaching a Paranormal Studies class at the local university. But Zuul, the all-powerful demon, has awakened from hibernation to wreak havoc on the unsuspecting masses. Desperate to recruit a new team, Egon and the plucky Janine turn to four of his teenage students: Kylie, a genius with an encyclopedic knowledge of the occult; Eduardo, a hip slacker with a crush on Kylie; Garrett, a wheelchair-bound athlete with a hot temper; and Roland, a “gentle giant” mechanical whiz. It's only a matter of time before Egon, Janine, old pal Slimer and the “kids” band together to rid the city of the evildoers.
Ghost Ghirls follows the comedic antics of two young female ghostbusters trying to solve the mysteries behind paranormal phenomena. Meanwhile, they attempt to convince their clients, some other-worldly visitors, and themselves that they are legit.
