Cast 21

1. 

   Ben Diskin

   Nigel 'Numbuh 1' Uno / Hoagie Pennywhistle 'Numbuh 2' Gilligan Jr / Numbuh 101 (voice)

2. 

   Lauren Tom

   Kuki 'Numbuh 3' Sanban (voice)

3. 

   Dee Bradley Baker

   Wally 'Numbuh 4' Beatles / Mr. Fibb / Toilenator / Joaquin / Tommy Gilligan (voice)

4. 

   Cree Summer

   Abigail 'Numbuh 5' Lincoln / Former Numbuh 11 - Cree Lincoln (voice)

5. Jason Harris

   Chad Dickson (voice)

6. 

   Grey DeLisle

   Crazy Old Cat Lady/Gramma Stuffum (voice)

7. 

   Jeff Bennett

   Mr. Boss / Mr. Fizz / Benedict Wigglestein (voice)

8. 

   Jennifer Hale

   Fanny 'Numbuh 86' Fulbright / Computer (voice)

9. 

   Mark Hamill

   Stickybeard (voice)

10. 

    Tom Kenny

    Knightbrace / Mr. Wink (voice)

11. 

    Maurice LaMarche

    Father (voice)

12. 

    Matt Levin

    Patton 'Numbuh 60' Drilovsky (voice)

13. 

    Frank Welker

    Monty Uno (voice)

14. 

    Neil Ross

    Grandfather (voice)

15. 

    Daran Norris

    Count Spankulot (voice)

16. 

    Rachael MacFarlane

    Rachael T. 'Numbuh 362' McKenzie (voice)

17. 

    Ogie Banks

    Sector Z Numbuh 0.1 - Bruce (voice)

18. 

    Janice Kawaye

    Sonya - Number 83 / Lee - Numbuh 84 (voice)

19. 

    Dave Wittenberg

    Numbuh Zero / Lenny - Sector Z Numbuh 0.4 (voice)

20. 

    Cam Clarke

    Additional Voices (voice)

21. 

    Candi Milo

    Additional Voices (voice)

Crew 8