PALI ROAD is a mysterious and thrilling journey in search for true love between two different worlds. Lily, a young doctor, wakes up from a car accident and discovers she is living a completely different life. Now married to her boyfriend’s rival, Dr. Mitch Kayne, and a mother to a 5-year-old son, she has an established life she remembers nothing about. Everyone around her denies that her boyfriend Neil ever existed. As Lily begins to doubt her own sanity, memories of Neil resurface, causing her to encounter unexplainable incidents. While desperately searching for the truth of her past life, she questions her entire existence; but in the end, she discovers the meaning of true love.

张莉莉（陈妍希 饰）学成毕业之后留在了美国一间医院里，成为了那里的实习生。每一天，她都要忍受上司麦奇医生（成康 饰）的各种苛责和挑剔，肩上的压力越来越重。就在这个节骨眼上，张莉莉邂逅了名为尼尔（杰克逊·拉斯波恩 Jackson Rathbone 饰）的男子，温柔体贴的尼尔让张莉莉很快就坠入了情网。